July 23, 2026 · 7 min read
Semaglutide vs Tirzepatide in San Antonio: Which One Should You Ask For?
A San Antonio peptide clinic compares semaglutide and tirzepatide head-to-head — expected weight loss, side effects, monthly cost, and how to pick between them.
By far the two most-asked GLP-1 questions in our San Antonio clinic right now: which one loses more weight, and which one is worth the extra money? Here's the honest side-by-side from a physician-supervised program.
The one-line summary
Tirzepatide (dual GLP-1 + GIP) generally produces more weight loss than semaglutide, at a higher monthly cost and slightly different side-effect profile. For most people, semaglutide is the smart place to start.
Expected weight loss
- Semaglutide: ~15% average body weight loss over 68 weeks in the STEP trials.
- Tirzepatide: ~20–22% average body weight loss over 72 weeks in the SURMOUNT trials.
- Real-world San Antonio results track a little lower because most patients don't stay on the highest dose.
Cost in San Antonio (2026 cash-pay)
- Compounded semaglutide: $250–$450/mo
- Compounded tirzepatide: $400–$700/mo
- Brand Wegovy or Zepbound without insurance: $1,000–$1,350/mo
Side effects — what actually differs
Both cause nausea, constipation, and appetite suppression in the titration phase. In practice, tirzepatide patients report slightly less nausea at equivalent weight-loss doses, likely because of the GIP component. Neither is a free ride — the first 2–4 weeks are the hardest for both.
Who should probably start with semaglutide
- First-time GLP-1 user with 20–40 lbs to lose
- Budget-sensitive and wants a lower monthly cost
- History of sensitive stomach — start low, go slow
Who tends to do better on tirzepatide
- 50+ lbs to lose or plateaued on semaglutide
- Type 2 diabetes or strong insulin-resistance markers
- Wants the best chance at the largest percentage loss
How we run it at Infinity Epigenetics
Every peptide program starts with a physician consult and baseline labs. We source only from licensed US compounding pharmacies, titrate slowly to minimize side effects, and pair the medication with body composition tracking, protein/nutrition guidance, and on-site recovery — red light and bioresonance — to protect muscle and manage stress.
Not sure which is right for you? Call (210) 900-2516 or visit 2015 NE Loop 410 in San Antonio for a consult.
Frequently asked questions
Can I switch from semaglutide to tirzepatide?+
Yes, with a physician-supervised transition. We typically finish a semaglutide dose cycle, then start tirzepatide at the low titration dose to keep side effects manageable.
Do either of these work without diet changes?+
You will lose weight either way from reduced appetite alone, but muscle preservation and long-term results depend on adequate protein and strength training. We build both into every program.
Is compounded semaglutide safe?+
When sourced from a licensed US 503A or 503B pharmacy under a valid prescription, yes. Avoid research-chemical or overseas sources — those are the ones producing headlines.
Ready to talk with our team?
San Antonio · Mon–Fri 9am–6pm · Walk-ins welcome
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